We have published an update for the project over at LEAF the org behind Lifespan.io where the MMTP raised funds for the project. We will be posting all future updates to the Project Update section over at LEAF and this website will remain for historical purposes. The update for September 25th, 2018 published on LEAF is shown below for your convenience but do check LEAF for future updates on the MMTP project as the project team members Elena and Steve have now moved over to LEAF to work fulltime for the org.
Hi everyone, it has been a long time so we thought it was time for a small update. We wanted to let you all know that the mouse study is underway in Germany, although we have been significantly delayed due to the strict regulations in Europe concerning animal welfare.
In Europe, there is a lot of paperwork to complete and high standards to reach before permission is granted for an animal study. We are pleased to confirm that after meeting those strict standards, the study was launched earlier this year at a facility near Leipzig, Germany.
We are testing six different senolytic or potentially senolytic drugs in various combinations, as multiple previous tests on senolytics done by other groups suggest that each one favors a different cell type. There are no previous studies exploring the potential of combinations of senolytics, with the exception of the work done with dasatinib and quercetin.
Many of the compounds that we are testing are known to target different types of senescent cells; therefore, a combination could potentially improve their efficiency, as Dr. Peter de Keizer recently suggested when he discussed senolytic “cocktails”.
Thank you once again to all our generous supporters who helped make the project a reality, and we hope that it leads to some interesting results once the research team publishes its findings.
The MMTP Team