Senescent cells

Senolytics: further health benefits discovered

Targeting senescent cells enhances adipogenesis and metabolic function in old age has been demonstrated in new research paper here. The researchers used a JAK inhibitor to reduce the negative signalling produced by senescent cells, whilst the results are interesting the better strategy here is to completely remove such cells and thus eliminate the need to manage the negative signallling.

Senolytics: A second drug shows promise

Senescence or the loss of a cells’ ability to divide, normally functions as a tumor suppressing mechanism; however, senescent cells become “toxic” as they accumulate with age. This is because they cause stem cell aging that reduces the ability of tissue regeneration and repair which then drives chronic inflammation and oxidative stress causing further damage and dysfunction. Since chronic inflammation and oxidative stress are thought to be the root cause of many age-related diseases,such as age-related osteoarthritis and atherosclerosis for example.

Senolytics: A new class of drugs

Senlyotics are a new class of drugs that help remove stubborn senescent cells that refuse to enter apopotosis (programmed cell death) and instead remain in the body sending out toxic signals which have a range of negative consequences. Senescent cells should be removed by the immune system or by their own self-destruction programs, however over time they escape this process and accumulate where they are not wanted, such as in the joints.