Targeting senescent cells enhances adipogenesis and metabolic function in old age has been demonstrated in new research paper here. The researchers used a JAK inhibitor to reduce the negative signalling produced by senescent cells, whilst the results are interesting the better strategy here is to completely remove such cells and thus eliminate the need to manage the negative signallling.
Senescence or the loss of a cells’ ability to divide, normally functions as a tumor suppressing mechanism; however, senescent cells become “toxic” as they accumulate with age. This is because they cause stem cell aging that reduces the ability of tissue regeneration and repair which then drives chronic inflammation and oxidative stress causing further damage and dysfunction. Since chronic inflammation and oxidative stress are thought to be the root cause of many age-related diseases,such as age-related osteoarthritis and atherosclerosis for example.